Academic Chapter Yoon Hang Kim MD 1. Introduction Methylene blue (3,7-bis(dimethylamino)-phenothiazin-5-ium chloride) is a synthetic heterocyclic aromatic compound with a medical history spanning nearly 150 years. Originally developed as an industrial textile dye, methylene blue entered medical practice in the late nineteenth century and
Supplement Memory
Supplements for Memory Loss Prevention: What the Evidence Actually Supports An evidence-ranked guide to the most-studied brain-health supplements By Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Few questions come up more often in my practice than this one: “What
When Low-Dose Naltrexone Triggers Insomnia: A Teaching Case on MCAS, POTS, Long COVID, and Medication Sensitivity Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician www.directintegrativecare.com Introduction In the landscape of complex chronic illness, clinicians frequently encounter patients whose physiology does
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CLINICAL REFERENCE NOTE Low-Dose Naltrexone (LDN) in Solid Organ Transplant Recipients on Chronic Immunosuppression Prepared by Yoon Hang Kim, MD, MPH | Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Reviewed: May 2026 | Internal clinical reference — not patient-facing Bottom line The concern is pharmacodynamic and entirely theoretical.
The Warburg Effect: A Century-Old Discovery That Still Shapes How We Think About Cancer Yoon Hang Kim MD MPH Board Certified, Preventive Medicine Practice of Yoon Hang Kim MD | www.directintegrativecare.com In 1924, a German biochemist named Otto Warburg made an observation about cancer cells that puzzled his
MCAS
Mast Cell Activation Syndrome (MCAS): A New Epidemic The Common Node of Long COVID, Lyme Disease, Mold Toxicity, and the Modern Chronic Illness Crisis Yoon Hang Kim, MD, MPH | Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Direct Integrative Care | Membership-Based Integrative Telemedicine | May 2026 ⚠ MEDICAL DISCLAIMER
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by Yoon Hang Kim MD Question: Can prednisone or other medications sometimes trigger a return of inflammatory pain symptoms in people who had previously been doing well on low-dose naltrexone (LDN)? For example, if someone had several months of significant pain relief on LDN, then developed an infection and
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Q: I'm trying to determine if the joint pain I am having can be from the LDN. I'm currently at 3 mg and my feet and thumbs have been hurting more and more. Thinking back I'm beginning to think it started increasing when I
McCullough Protocol
An evidence-aware academic review of the “base spike detoxification” regimen of nattokinase, bromelain, and curcumin Yoon Hang Kim, MD, MPH | Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician www.directintegrativecare.com Medical Disclaimer This article is for educational purposes only and does not constitute medical advice, diagnosis,
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Low-Dose Naltrexone and Gastrointestinal Health Mechanisms, Clinical Evidence, and Integrative Applications Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine Integrative & Functional Medicine Physician Abstract Low-dose naltrexone (LDN), administered at doses of approximately 0.5 to 4.5 mg daily, has emerged as a versatile off-
An Academic Book Chapter Yoon Hang "John" Kim, MD, MPH, FAAMA Practice of Yoon Hang Kim, MD San Antonio, TX www.directintegrativecare.com Serving MO May 2026 Copyright and Disclosures © 2026 by the author. This chapter is intended for academic and educational use. The material may be reproduced
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Start-Low-Go-Slow Protocols for MCAS, ME/CFS, and Autoimmune Disease Yoon Hang “John” Kim, MD, MPH, FAAMA Board-Certified Preventive Medicine | Integrative & Functional Medicine | LDN Research Trust Presenter The short version If you’ve been told LDN will make you better but every dose so far has