Mast Cell Activation Syndrome (MCAS): A New Epidemic The Common Node of Long COVID, Lyme Disease, Mold Toxicity, and the Modern Chronic Illness Crisis Yoon Hang Kim, MD, MPH | Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Direct Integrative Care | Membership-Based Integrative Telemedicine | May 2026 ⚠ MEDICAL DISCLAIMER This article
by Yoon Hang Kim MD Question: Can prednisone or other medications sometimes trigger a return of inflammatory pain symptoms in people who had previously been doing well on low-dose naltrexone (LDN)? For example, if someone had several months of significant pain relief on LDN, then developed an infection and was
Q: I'm trying to determine if the joint pain I am having can be from the LDN. I'm currently at 3 mg and my feet and thumbs have been hurting more and more. Thinking back I'm beginning to think it started increasing when I
An evidence-aware academic review of the “base spike detoxification” regimen of nattokinase, bromelain, and curcumin Yoon Hang Kim, MD, MPH | Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician www.directintegrativecare.com Medical Disclaimer This article is for educational purposes only and does not constitute medical advice, diagnosis, or treatment.
Low-Dose Naltrexone and Gastrointestinal Health Mechanisms, Clinical Evidence, and Integrative Applications Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine Integrative & Functional Medicine Physician Abstract Low-dose naltrexone (LDN), administered at doses of approximately 0.5 to 4.5 mg daily, has emerged as a versatile off-label therapy with proposed
An Academic Book Chapter Yoon Hang "John" Kim, MD, MPH, FAAMA Practice of Yoon Hang Kim, MD San Antonio, TX www.directintegrativecare.com Serving MO May 2026 Copyright and Disclosures © 2026 by the author. This chapter is intended for academic and educational use. The material may be reproduced
Start-Low-Go-Slow Protocols for MCAS, ME/CFS, and Autoimmune Disease Yoon Hang “John” Kim, MD, MPH, FAAMA Board-Certified Preventive Medicine | Integrative & Functional Medicine | LDN Research Trust Presenter The short version If you’ve been told LDN will make you better but every dose so far has made you worse, you
Integrative Oncology A Comprehensive Academic Synthesis of Mechanisms, Guidelines, Evidence, and Clinical Translation (2022–2026) An Academic Book Chapter Yoon Hang "John" Kim, MD, MPH, FAAMA Practice of Yoon Hang Kim, MD www.directintegrativecare.com San Antonio, Texas May 2026 Copyright and Disclosures © 2026 by the author. This
Pentosan Polysulfate Sodium and Oral Absorption: What Patients and Clinicians Need to Know Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician www.directintegrativecare.com MEDICAL DISCLAIMER This article is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. The information
Food Source vs. Water Source Mold: A Clinically Actionable Framework for Mold-Illness Management Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Direct Integrative Care Abstract Mold-related illness—encompassing Chronic Inflammatory Response Syndrome (CIRS), mast cell activation syndrome (MCAS) triggered by biotoxins, and other environmentally
The Practice of Yoon Hang Kim, MD Clinical Insights in Integrative & Functional Medicine Thymosin Alpha-1 in Integrative Oncology: Mechanisms, Clinical Evidence, and Emerging Applications Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician The Practice of Yoon Hang Kim, MD MEDICAL DISCLAIMER: This article
Adventurers of Elandris A Magical Empire ✶ ✶ ✶ Book 1: Venus Vanguard by John Kim A Note on the Timeline ~ ❧ ~ The events of this volume take place in a world that runs parallel to the Chronicles of Elandris, close enough that you will recognize its peoples and its purple sun, its dragons
Teaching Points 1. “Start Low and Go Slow” in Sensitive Patients Patients with chronic inflammatory, autoimmune, neurologic, or mast cell-related conditions may be highly sensitive to medications and supplements, including Low Dose Naltrexone (LDN). Starting with very low doses and increasing gradually can improve tolerability and reduce adverse effects. Symptom-guided
Mast Cell Activation Syndrome (MCAS): A New Epidemic The Common Node of Long COVID, Lyme Disease, Mold Toxicity, and the Modern Chronic Illness Crisis Yoon Hang Kim, MD, MPH | Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician www.directintegrativecare.com| Membership-Based Integrative Telemedicine | May 2026 ⚠ MEDICAL DISCLAIMER This article
www.directintegrativecare.com Beyond Burnout: Physician Moral Injury, Administrative Bloat, Vanishing Reimbursement, Mid-Level Encroachment, AI Anxiety, and the Systemic Collapse Reshaping American Medicine An Expanded Evidence-Based Academic Review Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Direct Integrative Care | May 2026 ⚠ MEDICAL & EDITORIAL
Testosterone
INTEGRATIVE HORMONE HEALTH | PEER-REVIEWED CLINICAL ANALYSIS Anastrozole and Clomiphene Citrate for Testosterone Optimization in Men: A Comprehensive Evidence-Based Review Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Published by Direct Integrative Care | Membership-Based Integrative Medicine Practice ABSTRACT Background: Male hypogonadism—characterized by deficient testosterone
LDN Primer
Dr. Kim's LDN Primer Book which covers basics of LDN is now available in Amazon - https://www.amazon.com/dp/B0GZ9R4667/ref=sr_1_1?crid=Y99J3Z8DLKY2&dib=eyJ2IjoiMSJ9.Kq_wzqE15_OGnVOgkdQHbQdwZK32CtfPr6H9aL8NtC2JdRuLQJkskth03cPcjIrlnpNzzTw6NqVAdjbFJvOflQ.owU6k5lJ4jkFwPod1eq9pIC126Fde8sml1nlDi_ameE&dib_tag=se&keywords=Low+Dose+Naltrexone+%28LDN%29+Primer%
hormone
CLINICAL EDUCATION SERIES Low-Dose Naltrexone and Hormonal Health: What the Evidence Actually Shows Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician www.directintegrativecare.com ABSTRACT Background: Low-dose naltrexone (LDN), administered at 1.5–4.5 mg nightly, is increasingly used off-label in integrative medicine
MCAS
Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician MEDICAL DISCLAIMER This article is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Mast Cell Activation Syndrome (MCAS) and histamine intolerance are highly individualized conditions, and probiotic responses can vary substantially
Integrative Oncology
INTEGRATIVE ONCOLOGY By Yoon Hang Kim, MD, MPH | Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Published by Yoon Hang Kim MD | Telemedicine across Iowa, Illinois, Missouri, Texas, Georgia & Florida ⚠ Medical Disclaimer This article is intended for educational purposes only and does not constitute medical advice. The therapies
Pediatric
Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Direct Integrative Care | Telemedicine Practice MEDICAL DISCLAIMER This article is for educational purposes only and does not constitute medical advice. Low-dose naltrexone (LDN) is used off-label in children and all pediatric use should be under the
Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Direct Integrative Care Published April 2026 MEDICAL DISCLAIMER: This article is for educational purposes only and does not constitute medical advice. Prolonged fasting carries real risks and should only be undertaken under the supervision of a
Yoon Hang Kim, MD, MPH | www.directintegrativecare.com KEY DISTINCTION: Removal from Category 2 does NOT equal Category 1 approval. Peptides removed from Category 2 currently occupy regulatory limbo as unapproved new drugs. Full legal compounding access requires PCAC review, a favorable recommendation, and final FDA rulemaking. Until that formal
Updated 4/28/2026 Integrative Functional Medicine Serving IA | IL | MO | GA | FL | TX Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician www.directintegrativecare.com A comprehensive examination of bioactive peptides for fitness, anti-aging, metabolism, cognition, and immune support ⚠️ DISCLAIMER: This review is for