Integrative Functional Medicine and LDN Community (Page 4)

The LDN–Cell Danger Response Convergence Hypothesis: Could Low-Dose Naltrexone Indirectly Modulate Purinergic Signaling in Chronic Subclinical Inflammation and HPG-Axis Suppression? — A Hypothesis

Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician What this article is — and is not. This is a hypothesis. It proposes a biologically plausible, testable model in which low-dose naltrexone (LDN) might indirectly influence purinergic “cell danger” signaling and, in turn, inflammation-

Pseudomonas aeruginosa in the Gut: When It Matters, How to Treat It, and an Honest Look at Botanicals and Probiotics

Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician ⚕ Medical Disclaimer This article is for educational and informational purposes only and does not constitute medical advice, diagnosis, or treatment. The strategies discussed should be implemented only under the guidance of a qualified healthcare provider.

Low-Dose Naltrexone and mTOR Inhibitor Therapy in Pediatric NPRL3-Related Focal Epilepsy with Neuroinflammation: A Clinical Review and Evidence-Based Dosing Framework

Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Published: July 2026 | www.directintegrativecare.com Medical Disclaimer: This article is intended for educational and clinical reference purposes only. It does not establish a physician–client relationship. All therapeutic decisions must be made by the

endometriosis

Endometriosis After Hysterectomy: Why Symptoms Persist and How to Treat Them

Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician For many women living with endometriosis, hysterectomy is offered — and often accepted — as the "definitive" solution to years of debilitating pelvic pain. Yet a meaningful number of women are dismayed to discover that

LDN MCAS

Low-Dose Naltrexone in the MCAS/POTS/hEDS Trifecta:Clinical Teaching Points for Ultra-Sensitive Clients

Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician July 2026 ⚠ IMPORTANT MEDICAL DISCLAIMER This article is for educational and informational purposes only and does not constitute medical advice, diagnosis, or treatment. Low-dose naltrexone (LDN) is not FDA-approved for mast cell activation

LDN teaching points from the education session.

Here are the key LDN teaching points extracted from the education session. LDN teaching points 1. Medication sensitivity can require ultra-low dosing Some MCAS/POTS/EDS patients may not tolerate standard LDN titration. In this case, even 1 microgram caused significant insomnia, suggesting the patient may need nanogram or

Radiation Protective Herbs

Herbs and Natural Compounds That Protect Normal Tissue During Radiation Therapy

Beyond Antioxidants: Through Non-Antioxidant Mechanisms Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Disclaimer: This article is for educational purposes only and does not constitute medical advice. The information presented summarizes preclinical and early clinical research. Herbs and supplements discussed here should

Mebendazole and Ivermectin in Integrative Oncology: A Rigorous Evidence-Based Evaluation of Repurposed Antiparasitic Agents in Cancer Care

Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician July 2026 ⚠ IMPORTANT MEDICAL DISCLAIMER This article is for educational and informational purposes only and does not constitute medical advice, diagnosis, or treatment. Neither mebendazole nor ivermectin is FDA-approved for any oncologic indication. The

insomnia integrative medicine

Insomnia Through an Integrative and Functional Medicine Lens

Bridging Conventional Sleep Medicine and Root-Cause Care: A Clinical Review Yoon Hang Kim, MD, MPHBoard-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Educational Disclaimer This article is provided for general educational purposes only and does not constitute medical advice, diagnosis, or treatment. It is not a substitute

Two Overlooked Mycotoxins on Your Panel:Where Citrinin and Mycophenolic Acid Come From — and How to Work Them Up

When a mycotoxin profile flags citrinin (reported as its urinary metabolite dihydrocitrinone) or mycophenolic acid, the reflex in many clinics is to assume a water-damaged building and reach for binders. That reflex is sometimes right and often premature. Both of these toxins carry a substantial dietary and pharmacologic footprint

aspirin bleeding risk

Aspirin and Bleeding Risk: What Every Client Taking Aspirin Should Understand — and Practical Strategies to Lower the Risk

Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Medical Disclaimer This article is for educational purposes only and does not constitute medical advice, nor does it establish a client-physician relationship. Aspirin is a medication with real risks, including serious bleeding. Whether to

dopamine LDN compt gene

The Low-Activity COMT Genotype: Understanding Dopamine Clearance Challenges and Evidence-Based Mitigation Strategies

Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician ⚠ MEDICAL DISCLAIMER This article is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider for diagnosis and treatment of any medical condition. Introduction Among the most clinically consequential

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