ldn
Feb 14, 2026 10:30 am FB Live Session What I’ve Learned from Two Decades of Prescribing Low Dose Naltrexone By Yoon Hang Kim, MD, MPH www.directintegrativecare.com I had a conversation with my LDN community recently—a live session where people brought their real questions, their real
ldn
Why the FDA’s Black Box Warning Doesn’t Apply to Low-Dose Naltrexone Yoon Hang Kim, MD, MPH Board Certified in Preventive Medicine | Fellowship Trained Integrative Medicine Physician | Institute of Functional Medicine Scholarship Recipient Direct Integrative Care | www.directintegrativecare.com If you’ve ever Googled naltrexone and liver safety, you’
ldn
Article of interest - Determining Optimal Beginning LDN Dose Abstract A common concern among patients considering low-dose naltrexone (LDN) therapy is whether chronic opioid receptor blockade might deplete endogenous endorphins, potentially causing dysphoria, anhedonia, or increased pain sensitivity. This comprehensive review examines the theoretical mechanisms, clinical evidence, and practical implications
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Yoon Hang “John” Kim, MD, MPH Board-Certified in Preventive Medicine | www.directintegrativecare.com February 2026 Key Takeaways * Autoimmune disease incidence and prevalence rise markedly with age, particularly after age 60, with some conditions peaking around age 70. * Immune aging (“immunosenescence”) drives this trend through thymic involution, T-cell senescence, impaired regulatory
yoon hang kim
Yoon Hang Kim, MD, MPH Board-Certified Preventive Medicine | Integrative & Functional Medicine LDN Expert | LDN Research Trust Presenter www.directintegrativecare.com I use works of great minds in my practice and this was brought to my attention from FB Group Root Cause Wellness Hub - https://www.facebook.com/groups/
ldn
Some of them aren't actually non-responders—they're people who started at a dose that was wrong for their body. They got side effects, felt worse, and gave up before LDN ever had a chance to work.
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Abstract Methylene blue has re-emerged as a promising therapeutic agent in functional and integrative medicine. This article reviews the historical journey of methylene blue from its origins through its pioneering use as t its current applications in mitochondrial support and neuroprotection.
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By calming neuroinflammation, boosting endorphin levels, and modulating immune function, LDN can help the nervous system learn to stop screaming.
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The key to optimizing LDN therapy is individualization. While bedtime dosing is standard and works well for most patients, listening to your body's response allows you to adjust timing for optimal benefit. Most side effects are mild, transient, and resolve within the first few weeks of therapy
MCAS
An Evidence-Based Guide to LDN, Ketotifen, and Integrative Therapies Yoon Hang Kim, MD, MPH Mast Cell Activation Syndrome (MCAS) is a complex and often underdiagnosed condition in which mast cells—an essential part of the immune system—become dysregulated and release mediators like histamine, prostaglandins, and cytokines inappropriately. This can
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When Theory Meets the Complexity of Human Physiology Yoon Hang Kim, MD, MPH One of the things I love about medicine is how often our patients humble us. We think we understand how a drug works, we have a beautiful mechanistic explanation—and then the body does something unexpected. Low-dose
Functional Medicine
A Functional Medicine Perspective on Genetics and Chronic Fatigue Syndrome Yoon Hang Kim MD I've been prescribing Low Dose Naltrexone for over two decades now, and one question comes up more than almost any other: "Why did LDN work miracles for my friend but barely touched my