ldn
Low-Dose Naltrexone: What It Is, How It Works, and Why Your Doctor May Not Have Mentioned It: A Plain-Language Guide from a Physician Who’s Prescribed It for Over 20 Years
LDN represents something powerful.
ldn
ldn
LDN Side Effects, Endorphin Depletion, and Why “Start Low and Go Slow” Matters
Feb 14, 2026 10:30 am FB Live Session What I’ve Learned from Two Decades of Prescribing Low Dose Naltrexone By Yoon Hang Kim, MD, MPH www.directintegrativecare.com I had a conversation with my LDN community recently—a live session where people brought their real questions, their real
ldn
LDN and Your Liver: Separating Myth from Evidence
Why the FDA’s Black Box Warning Doesn’t Apply to Low-Dose Naltrexone Yoon Hang Kim, MD, MPH Board Certified in Preventive Medicine | Fellowship Trained Integrative Medicine Physician | Institute of Functional Medicine Scholarship Recipient Direct Integrative Care | www.directintegrativecare.com If you’ve ever Googled naltrexone and liver safety, you’
ldn
Does Low-Dose Naltrexone Cause Endorphin Deficiency? Separating Mechanism from Myth in LDN Therapy
Article of interest - Determining Optimal Beginning LDN Dose Abstract A common concern among patients considering low-dose naltrexone (LDN) therapy is whether chronic opioid receptor blockade might deplete endogenous endorphins, potentially causing dysphoria, anhedonia, or increased pain sensitivity. This comprehensive review examines the theoretical mechanisms, clinical evidence, and practical implications
ldn
The Rising Tide of Autoimmunity in Aging: What the Evidence Tells Us and What It Means for Integrative Practice
Yoon Hang “John” Kim, MD, MPH Board-Certified in Preventive Medicine | www.directintegrativecare.com February 2026 Key Takeaways * Autoimmune disease incidence and prevalence rise markedly with age, particularly after age 60, with some conditions peaking around age 70. * Immune aging (“immunosenescence”) drives this trend through thymic involution, T-cell senescence, impaired regulatory
yoon hang kim
Ellen Langer and the Psychology of Possibility: How Actively Noticing Reshapes Health, Aging, and Human Potential
Yoon Hang Kim, MD, MPH Board-Certified Preventive Medicine | Integrative & Functional Medicine LDN Expert | LDN Research Trust Presenter www.directintegrativecare.com I use works of great minds in my practice and this was brought to my attention from FB Group Root Cause Wellness Hub - https://www.facebook.com/groups/
ldn
Finding Your LDN Sweet Spot: A Simple Guide to Optimal Dosing
Some of them aren't actually non-responders—they're people who started at a dose that was wrong for their body. They got side effects, felt worse, and gave up before LDN ever had a chance to work.
ldn
Low Dose Methylene Blue in Functional Medicine: Mitochondrial Support to Anti-Microbial Agent
Abstract Methylene blue has re-emerged as a promising therapeutic agent in functional and integrative medicine. This article reviews the historical journey of methylene blue from its origins through its pioneering use as t its current applications in mitochondrial support and neuroprotection.
ldn
Low-Dose Naltrexone and Neuroinflammation: What Two Decades of Prescribing Has Taught Me
By calming neuroinflammation, boosting endorphin levels, and modulating immune function, LDN can help the nervous system learn to stop screaming.
ldn
When to Take Low-Dose Naltrexone (LDN)
The key to optimizing LDN therapy is individualization. While bedtime dosing is standard and works well for most patients, listening to your body's response allows you to adjust timing for optimal benefit. Most side effects are mild, transient, and resolve within the first few weeks of therapy
MCAS
A Functional Medicine Approach to Mast Cell Activation Syndrome (MCAS)
An Evidence-Based Guide to LDN, Ketotifen, and Integrative Therapies Yoon Hang Kim, MD, MPH Mast Cell Activation Syndrome (MCAS) is a complex and often underdiagnosed condition in which mast cells—an essential part of the immune system—become dysregulated and release mediators like histamine, prostaglandins, and cytokines inappropriately. This can
ldn
LDN as a Prokinetic Agent (medicine that treats contstipation): In reality it can cause either constipation or diarrhea
When Theory Meets the Complexity of Human Physiology Yoon Hang Kim, MD, MPH One of the things I love about medicine is how often our patients humble us. We think we understand how a drug works, we have a beautiful mechanistic explanation—and then the body does something unexpected. Low-dose