Yoon Hang Kim MD

Board certified preventive medicine physician. University of Arizona fellowship grad. 20+ years prescribing LDN for chronic pain, autoimmune conditions & complex cases. Author. International speaker. Helping patients find answers.

ldn

Does Low-Dose Naltrexone Cause Endorphin Deficiency? Separating Mechanism from Myth in LDN Therapy

Article of interest - Determining Optimal Beginning LDN Dose Abstract A common concern among patients considering low-dose naltrexone (LDN) therapy is whether chronic opioid receptor blockade might deplete endogenous endorphins, potentially causing dysphoria, anhedonia, or increased pain sensitivity. This comprehensive review examines the theoretical mechanisms, clinical evidence, and practical implications

By Yoon Hang Kim MD
Understanding Magnesium Supplementation: A Comparative Analysis of Citrate, Glycinate, L-Threonate, Malate, and Oxide Forms

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Understanding Magnesium Supplementation: A Comparative Analysis of Citrate, Glycinate, L-Threonate, Malate, and Oxide Forms

Yoon Hang Kim, MD, MPH Abstract Magnesium is an essential mineral required for hundreds of enzymatic reactions, yet nearly half of U.S. adults fail to meet recommended dietary allowances. While various magnesium supplements are available, they differ significantly in bioavailability, gastrointestinal tolerance, and evidence for specific clinical indications. This

By Yoon Hang Kim MD

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The Rising Tide of Autoimmunity in Aging: What the Evidence Tells Us and What It Means for Integrative Practice

Yoon Hang “John” Kim, MD, MPH Board-Certified in Preventive Medicine  |  www.directintegrativecare.com February 2026 Key Takeaways * Autoimmune disease incidence and prevalence rise markedly with age, particularly after age 60, with some conditions peaking around age 70. * Immune aging (“immunosenescence”) drives this trend through thymic involution, T-cell senescence, impaired regulatory

By Yoon Hang Kim MD
The Shoemaker Protocol:A Comprehensive Review of the Diagnosis and Treatment of Chronic Inflammatory Response Syndrome (CIRS) - Mold Toxicity

mold

The Shoemaker Protocol:A Comprehensive Review of the Diagnosis and Treatment of Chronic Inflammatory Response Syndrome (CIRS) - Mold Toxicity

The Shoemaker Protocol: A Comprehensive Review of the Diagnosis and Treatment of Chronic Inflammatory Response Syndrome (CIRS) Yoon Hang Kim, MD, MPH Board-Certified Integrative Medicine Physician Disclaimer: This article is for educational and informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before

By Yoon Hang Kim MD