ENDORPHIN DEFICIENCY

ldn

Does Low-Dose Naltrexone Cause Endorphin Deficiency? Separating Mechanism from Myth in LDN Therapy

Article of interest - Determining Optimal Beginning LDN Dose Abstract A common concern among patients considering low-dose naltrexone (LDN) therapy is whether chronic opioid receptor blockade might deplete endogenous endorphins, potentially causing dysphoria, anhedonia, or increased pain sensitivity. This comprehensive review examines the theoretical mechanisms, clinical evidence, and practical implications