ldn
Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Function Medicine Physician • www.directintegrativecare.com 0:00 /1:07 1× Introduction One of the most common questions I encounter in my LDN practice—and in the LDN Support Group community of over 9,000 members—is this: “Why
ldn
1. Core Mechanism of LDN * Low Dose Naltrexone (LDN) temporarily blocks opioid receptors * This creates a transient drop in endorphins * The body typically responds by: * Increasing endogenous endorphin production * Leading to a rebound effect 2. Endorphin Deficiency Phenomenon * Not all patients compensate effectively * Some develop functional endorphin deficiency Clinical Presentation
ENDORPHIN DEFICIENCY
Chronic Pain, Non-Restorative Sleep, and Brain Fog as a Self-Reinforcing Cycle By Yoon Hang “John” Kim, MD, MPH Board-Certified Integrative Medicine Physician | Direct Integrative Care Abstract: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a complex, multi-system illness that remains a diagnosis of exclusion. While its etiology is incompletely understood,
ldn
Article of interest - Determining Optimal Beginning LDN Dose Abstract A common concern among patients considering low-dose naltrexone (LDN) therapy is whether chronic opioid receptor blockade might deplete endogenous endorphins, potentially causing dysphoria, anhedonia, or increased pain sensitivity. This comprehensive review examines the theoretical mechanisms, clinical evidence, and practical implications