crps
Low-Dose Naltrexone in Complex Regional Pain Syndrome:Mechanisms, Clinical Evidence, and Individualized Dosing Strategies
Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Abstract Complex Regional Pain Syndrome (CRPS) is a debilitating neuroinflammatory pain condition characterized by persistent disproportionate pain, autonomic dysregulation, vasomotor instability, and trophic changes. Its pathogenesis involves central sensitization, glial activation, and systemic immune dysregulation