rapamycine
An Evidence-Based Clinical Review Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician October 9, 2026 About Dr. Kim Yoon Hang Kim, MD, MPH is a board-certified physician with over 20 years of clinical experience spanning integrative medicine, functional medicine, medical acupuncture,
ME
By Yoon Hang "John" Kim, MD, MPH There is a phrase that has followed myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) for decades: diagnosis of exclusion. Taken too literally, it implies that clinicians arrive at ME/CFS only after exhausting every other possibility — as though the diagnosis is
ldn
Endorphin Depletion, Immune Dysregulation, and the Limits of Pharmacological Optimism Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Introduction: The Allure of a Universal Solution It is tempting to look at Low Dose Naltrexone (LDN) and see a single medication capable of addressing
LDN SIDE EFFECT
One of the most frequent questions I encounter in clinical practice is whether low-dose naltrexone (LDN) can worsen anxiety. The short answer is yes—it can happen, though the mechanism is more nuanced than a simple side effect.
ENDORPHIN DEFICIENCY
Chronic Pain, Non-Restorative Sleep, and Brain Fog as a Self-Reinforcing Cycle By Yoon Hang “John” Kim, MD, MPH Board-Certified Integrative Medicine Physician | Direct Integrative Care Abstract: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a complex, multi-system illness that remains a diagnosis of exclusion. While its
CFS
Chronic Fatigue Syndrome (CFS) and Myalgic Encephalomyelitis (ME) remain among the most misunderstood, underdiagnosed, and poorly managed conditions in modern medicine.
Functional Medicine
A Functional Medicine Perspective on Genetics and Chronic Fatigue Syndrome Yoon Hang Kim MD I've been prescribing Low Dose Naltrexone for over two decades now, and one question comes up more than almost any other: "Why did LDN work miracles for my friend but barely touched my